If you have never come across antidepressants while looking for effective solutions for your vulvar pain then this might be an option worth exploring.

Antidepressants remains a mainstay of treatment for vulvodynia in the medical community. Along with tricyclic antidepressants (TCAs), serotonin-norepinephrine reuptake inhibitors (SNRIs) have been used to treat vulvodynia, even though their effectiveness has not been proven in large controlled studies.

#1: What are SNRIs?

Serotonin-norepinephrine reuptake inhibitors (SNRIs) are a type of antidepressant. They were first introduced in the mid-1990s. They are also called dual reuptake inhibitors, dual-acting antidepressants and selective serotonin-norepinephrine reuptake inhibitors (SSNRIs).

#2: How do SNRIs work?

SNRIs are used to treat mental disorders (like depression and anxiety), behavioral disorders (such as OCD and ADHD), chronic neuropathic pain and fibromyalgia, stress urinary incontinence (SUI) in women, migraines and some syndromes of menopause.

SNRIs block or delay the absorption of brain chemicals called neurotransmitters (such as serotonin and norepinephrine). By doing this, SNRIs increase the level of neurotransmitters in the brain which enhances a person’s mood, alertness and decreases pain sensations.

#3: SNRIs for Vulvodynia

Please remember that although SNRIs are used in treating depression and anxiety, this does not mean that your pain is in your head.

Serotonin and norepinephrine are neurotransmitters that are responsible for regulating not just mental but also physical processes in your body. One of them is the regulation of pain sensations.

Because of that, like with other antidepressants, SNRIs also have off-label uses such as being a pain reliever to treat chronic pain conditions. SNRIs modify the way in which nerve fibers send impulses to the spinal cord to produce pain.

If you describe your vulvar pain as stabbing or shooting, and you have suspicion that your vulvodynia can originate from nerve malfunction (due to, for example, injury, surgery or diseases) called neuropathic pain, then your pain might be altered with SNRIs.

#4: Types of SNRIs for Vulvodynia Treatment

The most popular SNRIs used in modulating vulvar pain are:

  • Cymbalta (duloxetine) – tied for most popular
  • Effexor (venlafaxine) – tied for most popular
  • Pristiq (desvenlafaxine)
  • Fetzima (levomilnacipran)
  • Savella (milnacipran)

#5: SNRIs Dosage

The most popular SNRIs for vulvodynia are Cymbalta and Effexor.

Oral use

Oral doses start with a low dose, to avoid side effects. They are increased gradually every one to two weeks until the final dose is reached.


Some doctors start Effexor with a dose of 37.5 mg per day administered in the morning, with an increase to 75 mg daily after one to two weeks. If needed, the dose is changed every one to two weeks till the maximum dose of 150-225 mg is reached.


Some doctors start Cymbalta with a dose of 30 mg for one week. If symptoms persist, they increase the dose to total of 60 mg per day.

SNRIs don’t work overnight. Response to treatment can take up to several weeks nevertheless the first reduction in pain might be already noticeable after one to two weeks. However, it might take up to six to eight weeks of treatment to see full effects. The best results (as per patients’ experiences) are seen with daily doses of Effexor (150 – 225 mg) and Cymbalta (60 mg).

Effexor and Cymbalta have been used to treat vulvodynia, but their effectiveness has not been proven in large controlled studies.

#6: Best Practices for Using SNRIs


General Side Effects

Start from a low dose and slowly increase the amount to temper adverse side effects.

Sleeping difficulties

Take a pill during the morning hours to minimize sleeping difficulties at night.


Try taking medication with food to reduce nausea.

#7: SNRIs Side Effects

Serotonin and norepinephrine are heavily involved in physiological activities in your body. That is why while administering SNRIs for vulvodynia you might experience the following side effects:

  • Cardiovascular side effects, such as hypertension (increased blood pressure), increased heart rate, heart palpitations, lightheadedness when standing up due to a drop in blood pressure (orthostatic hypotension)
  • Gastrointestinal side effects, such as constipation, dry mouth, nausea, changes in appetite, weight gain
  • Nervous system side effects, such as dizziness, headaches (unrelated to blood pressure), drowsiness, lack of coordination, sleep disturbances (insomnia or hypersomnia), tremor, confusion, anxiety, agitation, memory loss
  • Abnormal bleeding
  • Muscle weakness
  • Difficulty urinating
  • Fluid retention
  • Abnormal sweating
  • Tiredness
  • Worsening liver problems (especially with Cymbalta)
  • Visual disturbances
  • Mydriasis (pupil dilation)
  • Low blood platelet count (thrombocytopenia)
  • Anemia
  • Hair loss (alopecia)
  • Consistent joint pain (arthralgia) and lupus-like syndrome
  • Reduced sexual desire or problems with sexual arousal
  • Increased risk of suicidal thoughts or behaviors

#8: SNRIs Interactions

IMPORTANT: Let your healthcare professional know if you are taking any other prescription and non-prescription medications, illegal, recreational, herbal, nutritional and dietary drugs.Some truly unpleasant side effects can be intensified.

NOTE: When taking a different antidepressant or another medicine that also has an effect on the chemical serotonin, you usually need at least a 2 week washout period (a period when you stop taking other medications) before starting SNRIs.

SNRIs interact with:

  • Alcohol
    • It may increase intoxication, drowsiness, and damage in the liver
  • A blood thinner medication like aspirin, warfarin (Coumadin, Jantoven).
    • It may raise the risk of abnormal bleeding
  • Nonsteroidal anti-inflammatory drugs (NSAIDs)
    • They can also increase the risk of abnormal bleeding
  • Medications that increase serotonin levels which can cause anxiety, agitation, sweating, confusion, tremors, restlessness, rapid heart rate. These medications include:
    • Other antidepressants like SSRIs (selective serotonin receptor inhibitors), TCAs (Tricyclic Antidepressants), MAOIs (monoamine oxidase inhibitors)
    • Complementary medicine, herbs, supplements containing St John’s Wort
    • Migraine and headache medicine like sumatriptan, zolmitriptan
    • Pain medication such a Tramadol
    • Over-the-counter cough medicine containing dextromethorphan
  • Opioid medication, sleeping pills, muscle relaxers or medicine for anxiety or seizures.
    • It can make the drowsy effect worse
  • Mood disorder and mental illness medication like buspirone (anti-anxiety medication), lithium (bipolar disorder, manic episodes)
  • Acid drugs such as cimetidine
  • Tryptophan (sometimes called L-tryptophan)
  • Vitamins, herbal products, and supplements

#9: SNRI Contraindications and Warnings

1. If you are pregnant (or planning to get pregnant):

Antidepressants are not recommended and should not be used if you are pregnant, breastfeeding or trying to conceive.

SNRIs increase the chances of miscarriage by 68% and combining antidepressants may double miscarriage risk. Effexor alone was shown to slightly increase the risk of spontaneous abortion. Additionally, SNRIs are passed into breast milk.

Newborn babies whose moms were talking SNRIs during the second half of pregnancy might experience withdrawal symptoms like:

  • Difficulty breathing
  • Feeding problems
  • Tremors

Please talk to your doctor about possible risks to you and your baby, in order to weigh these risks against the benefits of using SNRIs.

2. If you have liver damage:

SNRIs are processed in your liver. If you suffer from liver problems, then more of the drug might stay longer in your system increasing the risk of side effects.

3. If you have high blood pressure:

SNRIs can increase blood pressure levels.

#10: SNRIs Discontinuation

Like with other antidepressants, SNRIs can produce a withdrawal – also called discontinuation syndrome – if you suddenly stop taking them or miss several doses of the drug.

You can minimize these symptoms by introducing a washout period – reducing your dosage over a period of at least 15 to 20 days and up to several months.

You might experience more withdrawal symptoms while taking venlafaxine and desvenlafaxine.

Withdrawal symptoms might include:

  • Anxiety
  • Urgent need to urinate
  • Diarrhea
  • Dizziness
  • Tiredness, chills, muscle aches, or other flu-like symptoms
  • Headaches
  • Lethargy
  • Irritability or agitation


In this post, you can find general information about SNRIs (Serotonin-Norepinephrine-Reuptake-Inhibitors) for vulvodynia:

  • What SNRIs are and how they work
  • How and which SNRIs can help with your vulvar pain
  • Initial guidelines of how to take SNRIs
  • What types of side effects you might experience, including  withdrawal symptoms and what you can do about them
  • Possible interactions, contraindications, and warnings

Please don’t feel discouraged if you feel little to no relief while taking SNRIs or if your pain will come back after the discontinuation of the medication.

Please keep in mind that SNRIs like other types of traditional medications might not treat nor heal the underlying root cause of your vulvar pain. Rather than temporarily eliminating and curing evidence of the illness or masking the symptoms. SNRIs also don’t heal your body.

Please remember that SNRIs are definitely not the only solution available for vulvodynia. There are still other medical and natural remedies that you can explore.

Did you find this post helpful? If so what other types of information would you like me to share with you?

Have you ever taken SNRIs for vulvar pain? Did SNRIs help your symptoms?

Share with me all of your thoughts, experiences, and questions in the comments below! You can also ask me anything directly on FB.


My goal is to provide you with the most relevant and current information that is factually correct, comprehensive and up-to-date.

However, the drug information provided herein is subject to changes and is not intended to cover all possible:

  • Uses
  • Dosage indications and best practices for usage
  • Side effects
  • Drug interactions
  • Contraindications and warnings
  • Drug withdrawal symptoms

Additionally, each person is different and may respond differently to the drug.

Please also bear in mind, that this article should not be used as a substitute for the knowledge and expertise of a doctor or other licensed healthcare professionals. Please before taking any medication, consult it with your health provider, who knows your medical history.


Because life’s too short. And you deserve to be healthy + happy.

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The Definitive Guide to SNRIs for Vulvodynia

time to read: 10 min